Mfantsiman Girls Senior High School was founded by the late Osagyefo Dr. Kwame Nkrumah, the President of the first Republic of Ghana, as a special gesture of appreciation to the people of Saltpond for the part the town played in the political history of the country. The school was formally known as Salptond Girls Secondary School and later changed to Mfantsiman Girls when the district of Saltpond became the Mfantseman Municipal Assembly.

A group of prominent persons were selected to choose the site for the school. They included Mr. Kojo Botsio – Minister of Education, Mr. Kofi Baako – Member of Parliament for Saltpond, Mr. George Padmore. West Indian Africanist, Dr. Hastins Banda – President of Republic of Malawi and Mr. S. E. Arthur – Member of the school Board of Governors.

The site identified for the school was the “Kuntupow”, where the school now stands. Actual construction works began in 1958 on a land size measuring 430.10 acres. In September 1958, the first phase, consisting of the Administration Block, Classroom Block, Science Block, Dining Hall, a teacher’s bungalow and the Headmistress’s bungalow were started and completed in 1960.

On 23rd September, 1960 students were selected through the late entrance of the West African Entrance Examination Council and interviewed. On 30th September, 1960, a Ghana Education Trust (GET) school, opened its gates to its first students, who were seventy (70) in number. Four (4) teachers including the Headmistress, Mrs. Beatrice AhineChinery, were at the helm of affairs. By 1961, the number of students in the school had increased to 140.

Initially, the school uniform was green in colour and was changed to brown and then to mauve which has been maintained to date.

The school anthem then, was a song in Latin. This was, however, replaced by the current one “ɔbra nye woara bɔ” (life is what you make it).

In June 1965, the first batch of 5th formers took the General Certificate Education (GCE) ‘O’ Level Examination. Between 1964 and 1967, the second phase of the school construction was completed. This comprised the third dormitory block named Engmann House and the first block of living apartment for staff. It was during this time that the school’s overhead water tank was connected to Baifikrom water Works due to the erratic nature of the Brimso Water supply. The school also got connected to the Akosombo electricity grid during the same period.

In 1968, the Sixth Form Arts and Science was introduced. Initially it was difficult getting girls to offer Science subjects and so from September 1969 to June 1976 the first batch of boys was admitted to the Sixth Form to take science to encourage the girls to offer science subjects. These boys were popularly known as the “She-boys”. The fourth dormitory block was added in the same year and named after another former Headmistress Miss. Doris E. Scotton.

As the number of the teachers increased there was the need for a primary school for teachers’ children. A play school was started by Mrs. Park who was a spouse of an expatriate teacher to cater for the children of staff. This set the tone for the establishment of the basic school on the compound.

In order to forestall the frequent turnover in teaching staff and to ensure sustenance and continuity of quality education in the school and good discipline, a strong and vibrant Parent/Teacher Association (PTA) was formed and has supported the school till now.

In the early 1980’s an appeal was made to the Canadian High Commission in Accra for assistance to construct a primary school. In response to the school’s appeal, the commission constructed a permanent building for the primary school.

The PTA in 1998 constructed the 5th dormitory to alleviate the acute accommodation challenges in the school due to an alarming increase in population. This house was named after Mrs. Elizabeth A. Croffie, the then Headmistress of the school. In 2009 the sixth dormitory was built and named after another former Headmistress, Mrs. Vida Yeboah. During the administration of Mrs. Sarah V. Wilson (Headmistress) an internet facility (ICT Lab) was installed for the school.

Since its establishment, the school has churned out over 11,000 students including 18 boys with School Certificate/General Certificate of Education. Ordinary Level and Advanced Level Certificate, Senior Secondary School Certificate and Senior High School Certificate. Majority of the school’s products have become prominent members of society, both home and abroad.

As the number of students continued to increase, the total number of staff also increased in proportion. This necessitated the construction of additional facilities, thus in 2001, the PTA, under the Chairmanship of Madam Joana F. Dickson, built an additional Dining Hall and transit quarters for staff. They also upgraded the area in front of the school wall in July 2010.

The Government of Ghana came to the aid of the school and built a six-shed classroom for students due to the increasing number of girls in the school. The P.T.A. again refurbished an old classroom block which was abandoned for years in order to ease congestion in the classrooms. Another classroom block, popularly referred to as the Green Belt, was built by an NGO.

As the student population increased, the school chapel which was used for church services and as an assembly hall could not contain both students and staff. Mrs. Elizabeth Croffie sought help from the government for an assembly hall for the school. The foundation stone was laid during her administration and today the school can boast of a 2000 seater auditorium for students and staff. Currently a 24 unit classroom block, a 12 unit classroom block and two new dormitory blocks, funded by GET fund are under construction.

In order to unearth the talents of students, the Regimental Band and School Cadet were established. They have been performing excellently since their establishment. Currently, the school can boast of a very vibrant sports and games team which has won several laurels in the region and at the national level. The school can also boast of several social clubs such as Adolescent Reproductive Club, Child’s Right, Parliamentary Club, Writers and Debaters Club, Drama Club among many others. Many have also won several awards.

The Old Students Association (MOGA), has been instrumental in the welfare of staff, students’ academic work and infrastructural development of the school. The 1987/93/95 old students donated street solar lights and Solar panels to light all the classrooms in the form three block and the school compound.